Cppyy is an automatic, run-time, Python-C++ bindings generator, for calling C++ from Python and Python from C++. Run-time generation enables detailed specialization for higher performance, lazy loading for reduced memory use in large scale projects, Python-side cross-inheritance and callbacks for working with C++ frameworks, run-time template instantiation, automatic object downcasting, exception mapping, and interactive exploration of C++ libraries. cppyy delivers this without any language extensions, intermediate languages, or the need for boiler-plate hand-written code.